Preparation, Characterization and Biological Activity Screening on Some Metal Complexes Based of Schiff Base Ligand

A novel Schiff base ligand named (E)-2-(((3-hydroxyphenyl)imino)methyl)phenol (H2L) was prepared through condensation of 2-hydroxybenzaldehyde with 3-aminophenol in1:1 ratio. The characterized using spectroscopic techniques. La(III), Er(III) and Yb(III) complexes derived from H2L have been by conventional techniques including elemental analyses, infrared, electronic spectra, mass molar conductivity thermal analysis. IR spectral data showed that is coordinated to the metal ions in a bi-negative tridentate manner azomethine nitrogen two deprotonated phenolic oxygen atoms. thermogravimetric analysis displays existence hydrated water molecules complexes. its were evaluated for their antibacterial antifungal activities against different gram positive bacteria (Staphylococcus Aureus Bacillis subtilis), negative (Salmonella SP., Escherichia Coli Pseudomonas aeruginosa) fungi (Aspergillus Fumigates Candida albicans). found higher biological activity more than ligand. calculated binding energy values receptors colon cancer (PDB code: 2hq6) lung 1x2j) discussed.